Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease
Identifieur interne : 000216 ( France/Analysis ); précédent : 000215; suivant : 000217Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease
Auteurs : A.-C. Bachoud-Lévi [France] ; C. Bourdet [France] ; P. Brugières [France] ; J.-P. Nguyen [France] ; T. Grandmougin [France] ; B. Haddad [France] ; R. Jény [France] ; P. Bartolomeo [France] ; M.-F. Boissé [France] ; G. Dalla Barba [France] ; J.-D. Degos [France] ; A.-M. Ergis [France] ; J.-P. Lefaucheur [France] ; F. Lisovoski [France] ; E. Pailhous [France] ; P. Rémy [France] ; S. Palfi [France] ; G. L. Defer [France] ; P. Cesaro [France] ; P. Hantraye [France] ; M. Peschanski [France]Source :
- Experimental Neurology [ 0014-4886 ] ; 1999.
English descriptors
Abstract
This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.
Url:
DOI: 10.1006/exnr.1999.7239
Affiliations:
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Peschanski</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="ISSN">0014-4886</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">161</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="194">194</biblScope><biblScope unit="page" to="202">202</biblScope></imprint><idno type="ISSN">0014-4886</idno></series><idno type="istex">D64682DFDD7E38D56E3B9F94E88EDC0FA406447E</idno><idno type="DOI">10.1006/exnr.1999.7239</idno><idno type="PII">S0014-4886(99)97239-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>fetal neural transplants.</term><term>safety and tolerability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Caen</li><li>Créteil</li><li>Orsay</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Bachoud Levi, A C" sort="Bachoud Levi, A C" uniqKey="Bachoud Levi A" first="A.-C." last="Bachoud-Lévi">A.-C. Bachoud-Lévi</name></region><name sortKey="Barba, G Dalla" sort="Barba, G Dalla" uniqKey="Barba G" first="G. Dalla" last="Barba">G. Dalla Barba</name><name sortKey="Bartolomeo, P" sort="Bartolomeo, P" uniqKey="Bartolomeo P" first="P." last="Bartolomeo">P. Bartolomeo</name><name sortKey="Boisse, M F" sort="Boisse, M F" uniqKey="Boisse M" first="M.-F." last="Boissé">M.-F. Boissé</name><name sortKey="Bourdet, C" sort="Bourdet, C" uniqKey="Bourdet C" first="C." last="Bourdet">C. Bourdet</name><name sortKey="Brugieres, P" sort="Brugieres, P" uniqKey="Brugieres P" first="P." last="Brugières">P. Brugières</name><name sortKey="Cesaro, P" sort="Cesaro, P" uniqKey="Cesaro P" first="P." last="Cesaro">P. Cesaro</name><name sortKey="Defer, G L" sort="Defer, G L" uniqKey="Defer G" first="G. L." last="Defer">G. L. Defer</name><name sortKey="Degos, J D" sort="Degos, J D" uniqKey="Degos J" first="J.-D." last="Degos">J.-D. Degos</name><name sortKey="Ergis, A M" sort="Ergis, A M" uniqKey="Ergis A" first="A.-M." last="Ergis">A.-M. Ergis</name><name sortKey="Grandmougin, T" sort="Grandmougin, T" uniqKey="Grandmougin T" first="T." last="Grandmougin">T. Grandmougin</name><name sortKey="Haddad, B" sort="Haddad, B" uniqKey="Haddad B" first="B." last="Haddad">B. Haddad</name><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P." last="Hantraye">P. Hantraye</name><name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R." last="Jény">R. Jény</name><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J.-P." last="Lefaucheur">J.-P. Lefaucheur</name><name sortKey="Lisovoski, F" sort="Lisovoski, F" uniqKey="Lisovoski F" first="F." last="Lisovoski">F. Lisovoski</name><name sortKey="Nguyen, J P" sort="Nguyen, J P" uniqKey="Nguyen J" first="J.-P." last="Nguyen">J.-P. Nguyen</name><name sortKey="Pailhous, E" sort="Pailhous, E" uniqKey="Pailhous E" first="E." last="Pailhous">E. Pailhous</name><name sortKey="Palfi, S" sort="Palfi, S" uniqKey="Palfi S" first="S." last="Palfi">S. Palfi</name><name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M." last="Peschanski">M. Peschanski</name><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P." last="Rémy">P. Rémy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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